Fluticasone propionate CAS No.80474-14-2 / Cat No.EBD45417
(6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester
(6alpha,8xi,11beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propanoate
(6alpha,11beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propanoate
S-(fluoromethyl) (6alpha,11beta,16alpha,17alpha)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioate
(6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester
(6alpha,8xi,11beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propanoate
(6alpha,11beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propanoate
S-(fluoromethyl)
Properties
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Appearance:
Crystalline solid
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Density:
1.32 g/cm3
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Melting point:
275 °C
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Boiling point:
568.3 °C at 760 mmHg
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Flashing point:
297.5 °C
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Coefficient of refraction:
31 ° (C=1, Dioxane)
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Solubility:
DMSO: ≥10 mg/mL
Safety Information
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Signal words:
None
NMR Spectrum
Prediction： H-NMR, 200 MHz: in CDCI3 ; 8 1. 01 (d, 3H, ME16, J=7.4 Hz); 1.12 (t, 3H, OCCH2Me, J=7.5 Hz); 1.19 (s, 3H, ME18) ; 1.54 (s, 3H, ME19) ; 2.39 (q, 2H, OCCH2Me, J=7.5 Hz); 3,40 (m, 1H) ; 4.41 (m, 1H, H11) ; 5.25-5. 60 (dddd, 1H, H6, J=1.8, 6.2, 11.0, 48.2 Hz); 5.70-6. 10 (dqAB, 2H, SCHaF, J=9.6, 50.0 Hz); 6.41 (dd, 1H, H2, J=1.8, 10.5 Hz); 6.47 (m, 1H, H4); 7.14 (dd, 1H, H1, J=1.4, 10.5 Hz). The signals of the other protons fall between 1.2 and 2.6 ppm.
1H NMR
13C NMR
