Gefitinib CAS No.184475-35-2 / Cat No.EBD446
吉非替尼
N-(3-氯-4-氟苯基)-7-甲氧基-6-(3-吗啉-4-丙氧基)喹唑啉-4-胺
易瑞沙(阿斯利康公司的抗肿瘤新药)
吉非替尼(易瑞沙)
吉非替尼
4-[(3-氯-4-氟苯基)氨基]-6-[3-(4-吗啉基)丙氧基]-7-甲氧基喹唑啉
N-(3-氯-4-氟苯基)-7-甲氧基-6-(3-吗啉丙氧基)喹唑啉-4-胺
吉非替尼 (ZD1839)
Properties
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Appearance:
light-yellow crystalline powder
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Density:
1.322 g/cm3
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Melting point:
119-1200C
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Boiling point:
586.8 °C at 760 mmHg
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Flashing point:
308.7 °C
Safety Information
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Symbol:
-
Signal words:
Warning -
Hazard statements:
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
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Precautionary statements:
P301+P312+P330 IF SWALLOWED:Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
NMR Spectrum
Prediction： 1H NMR (400 MHz, d6-DMSO) O 9.44 (5, 1H), 8.50 (5, 1H), 8.12 (dd, J= 6.9, 2.7 Hz,1H), 7.80 (m, 2H), 7.44 (t, 1H), 7.20 (5, 1H), 4.18 (t, J= 6.7 Hz, 2H), 3.94 (5, 3H), 3.59(t, J = 4.4 Hz, 4H), 2.49 (t, J = 6.9 Hz, 2H), 2.41 (bs, 4H), 2.00 (m, 2H).
1H NMR
13C NMR
