R-(-)-Flecainide, CAS No. 99495-90-6

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99495-90-6

Catalog No. EBD3317259

CAS 99495-90-6

Name R-(-)-Flecainide

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Basic Information

Synonyms: (r)-(-)-flecainide (r)-flecainide benzamide,n-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-,(r)- benzamide,n-[(2r)-2-piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)- n-[(2r)-2-piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide n-[(r)-2-piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide R-(-)-Flecainide N-[(2R)-piperidin-2-ylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide R-(–)-Flecainide

Molecular Formula: C17H20F6N2O3

Molecular Weight: 414.34

Categories: Medicinal Chemistry > APIs and Their Salts > Cardiovascular Drugs

Product Description:

R-(-)-Flecainide is the (R)-enantiomer of flecainide acetate, a class Ic antiarrhythmic agent. It is a chiral molecule with a fluorinated aromatic ring and an amide linkage. The (R)-enantiomer is one of the two stereoisomers of the drug substance. This compound is primarily used as an active pharmaceutical ingredient (API) for the treatment of life-threatening ventricular arrhythmias, such as sustained ventricular tachycardia. It functions as a potent sodium channel blocker, slowing conduction in the heart's His-Purkinje system and ventricles. Flecainide is also indicated for the prevention of paroxysmal atrial fibrillation/flutter and paroxysmal supraventricular tachycardias. The development and use of the individual enantiomer, R-(-)-flecainide, are of interest in pharmaceutical research to understand potential differences in pharmacokinetics, efficacy, or side-effect profiles compared to the racemic mixture. It is handled as a high-potency active substance, requiring appropriate safety precautions.

Physical Properties

Boiling Point: 434.9°C at 760 mmHg

Flash Point: 216.8°C

Density: 1.286g/cm3