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    98919-68-7

    Catalog No. EBD2205230

    CAS 98919-68-7

    Name (-)-(1R,2S)-2-phenyl-1-cyclohexanol

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    Basic Information

    Synonyms: (-)-(1R,2S)-trans-2-phenylcyclohexanol (1r,2s)-(-)-trans-2-phenyl-1-cyclohexanol (1r,2s)-trans-2-phenyl-1-cyclohexanol (1r,2s)-(-)-trans-2-phenyl-1-cyclohexanol,99%(99%ee/glc) (1r,2s)-2-phenyl-cyclohexanol (1r-trans)-2-phenylcyclohexanol

    Molecular Formula: C12H16O

    Molecular Weight: 176.25

    MDL Number: MFCD00075488

    Categories: Synthetic Chemistry > Organic Building Blocks > Other Organic Building Blocks Synthetic Chemistry > Catalysts and Ligands > Chiral Ligands

    Product Description:
    (1R,2S)-(-)-trans-2-Phenyl-1-cyclohexanol is a chiral cyclohexanol derivative characterized by its trans configuration and the presence of a phenyl substituent at the 2-position. It is a valuable chiral building block and auxiliary in organic synthesis, particularly due to its well-defined stereochemistry which can be used to induce asymmetry in chemical reactions. Its primary application lies in asymmetric synthesis, where it serves as a chiral ligand precursor or a chiral auxiliary. The molecule's rigid cyclohexane ring and the hydroxyl group provide a scaffold for coordinating to metals or for temporary attachment to substrates to control the stereochemical outcome of transformations such as reductions, alkylations, or cycloadditions. It is a key intermediate in the synthesis of more complex chiral molecules for pharmaceutical and material science research. This compound is typically handled as a solid and requires storage under inert conditions to preserve its optical purity. It is considered a specialty fine chemical used primarily in research and development settings for the construction of enantiomerically enriched compounds.
    Physical Properties

    Melting Point: 63-66 °C(lit.)

    Boiling Point: 276-281 °C(lit.)

    Flash Point: 113.326 °C

    Density: 1.051 g/cm3

    Refractivity: -58 ° (C=1, MeOH)

    mg g kg ml l t