(4S)-4-(2-Chlorophenyl)-2-hydroxy-5,5-dimethyl-1,3,2-dioxaphosphinane 2-oxide, CAS No. 98674-86-3

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98674-86-3

Catalog No. EBD10466

CAS 98674-86-3

Name (4S)-4-(2-Chlorophenyl)-2-hydroxy-5,5-dimethyl-1,3,2-dioxaphosphinane 2-oxide

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Basic Information

Synonyms: (4S)-4-(2-Chlorophenyl)-2-hydroxy-5,5-dimethyl-1,3,2-dioxaphosphinane2-oxide (s)-(-)-4-(2-chlorophenyl)-2-hydroxy-5,5-dimethyl-1,3,2-dioxaphosphorinane2-oxide (s)-(-)-4-(2-chlorophenyl)-2-oh-5,5-di-me-1,3,2-dioxaphosphorinane2-oxide,97% (s)-(-)-4-(2-chlorophenyl)-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane- (s)-(-)-chlocyphos (s)-(-)-chlocyphos(en) (4s)-(-)-4-(2-chlorophenyl)-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphinane2-oxide (s)-(-)-chlocyphos,(4s)-(-)-4-(2-chlorophenyl)-5,5-dimethyl-1,3,2-dioxaphosphinan-2-ol2-oxide (S)-(-)-4-(2-chlorophenyl)2-hydroxy-5,5-dimethyl1,3,2-dioxaphosphorinane2-oxide (S)-(-)-4-(2-chlorophenyl)-2-oh-5,5-di-me-1,3,2-D (S)-()-4-(2-Chlorophenyl)-2-hydroxy-5,5-dimethyl-1,3,2-dioxaphosphorinane2-oxide (4S)-4

Molecular Formula: C11H14ClO4P

Molecular Weight: 276.65

MDL Number: MFCD00055615

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Phosphorus Compounds

Product Description:

(S)-(-)-4-(2-Chlorophenyl)-2,5,5-trimethyl-2-hydroxy-1,3,2-dioxaphosphorinane 2-oxide is a chiral organophosphorus compound featuring a 1,3,2-dioxaphosphorinane ring system. It is characterized by a phosphorus atom in a P(V) oxidation state, bearing a hydroxyl group and an oxide, and is substituted with a 2-chlorophenyl group and three methyl groups. This specific stereochemistry is crucial for its application. This compound serves as a key chiral intermediate in the synthesis of biologically active molecules. Its primary application is in the pharmaceutical industry for the production of Clopidogrel, a widely used antiplatelet drug (a thienopyridine P2Y12 receptor antagonist). The chiral phosphorus center in this intermediate is instrumental in establishing the desired stereochemistry of the final active pharmaceutical ingredient (API), which is essential for its therapeutic efficacy and safety profile. As a specialized chiral building block, it is not a commodity chemical but a high-value intermediate used in asymmetric synthesis routes. Its handling requires standard precautions for organophosphorus compounds, although its specific safety profile is tied to its use in controlled manufacturing environments.

Physical Properties

Melting Point: 228-234 °C(lit.)