Benzofuran-2-boronic acid, CAS No. 98437-24-2

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98437-24-2

Catalog No. EBD1615658

CAS 98437-24-2

Name Benzofuran-2-boronic acid

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Basic Information

Synonyms: 1-Benzofuran-2-ylboronicacid Benzofuran-2-ylboronicacid Benzofuran-2-boronicacid Benzo(b)furan-2-boronicacid 2-benzofuranboronicacid 2,3-benzobfuran-2-boronicacid akosbrn-0027 rarechemahpb0159

Molecular Formula: C8H7BO3

Molecular Weight: 161.95

Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

Benzo[b]furan-2-boronic acid is an organoboron compound featuring a benzo[b]furan core structure functionalized with a boronic acid group at the 2-position. It is a white to off-white solid powder commonly used as a versatile building block in organic synthesis. Its primary application is as a key reagent in Suzuki-Miyaura cross-coupling reactions, a widely employed method for forming carbon-carbon bonds. The boronic acid group enables efficient palladium-catalyzed coupling with various aryl or vinyl halides. Due to its benzo[b]furan scaffold, it serves as a crucial intermediate in the synthesis of numerous pharmaceuticals, agrochemicals, and functional materials, particularly those requiring the benzofuran moiety. It is frequently utilized in medicinal chemistry research for constructing drug-like molecules and bioactive compounds. This compound should be handled with care under inert atmosphere (e.g., nitrogen or argon) to prevent decomposition, as boronic acids can be sensitive to protic solvents and air over time. It is typically stored at low temperatures (2-8°C).

Physical Properties

Melting Point: 114-116 °C(lit.)

Boiling Point: 340.4 °C at 760 mmHg

Flash Point: 159.7 °C

Density: 1.31 g/cm3

Analytical Data

Appearance: white to light yellow crystal powder