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    98303-20-9

    Catalog No. EBD933915

    CAS 98303-20-9

    Name 1-tert-Butoxycarbonyl-piperidine-2-carboxylic acid

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    Basic Information

    Synonyms: rac1-boc-piperidine-2-carboxylicacid (R)-1-N-BOC-PIPERIDINE-2-CARBOXYLICACID

    Molecular Formula: C11H19NO4

    Molecular Weight: 229.27

    MDL Number: MFCD01862877

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    N-Boc-DL-piperidine-2-carboxylic acid is a heterocyclic organic compound featuring a piperidine ring core. It is a racemic mixture (DL-form) where the amino group on the piperidine nitrogen is protected by a tert-butoxycarbonyl (Boc) group, and the carboxylic acid functionality is present at the 2-position. This dual functionality makes it a versatile chiral building block. This compound is primarily employed as a key intermediate in pharmaceutical synthesis. The Boc-protected amine is stable under many reaction conditions but can be readily deprotected under acidic conditions, allowing for selective manipulation of the molecule. The carboxylic acid group serves as a handle for further derivatization, such as amide bond formation. It is particularly valuable for constructing complex molecules containing the piperidine scaffold, which is a privileged structure found in numerous bioactive compounds and active pharmaceutical ingredients (APIs) targeting the central nervous system and other therapeutic areas. As a protected amino acid derivative, it is a standard reagent in medicinal chemistry and peptide mimetic research. Its role is fundamental in constructing molecular diversity libraries and in the synthesis of potential drug candidates where the piperidine moiety is required.
    Physical Properties

    Melting Point: 130-133 °C(lit.)

    Boiling Point: 353.2 °C at 760 mmHg

    Flash Point: 167.4 °C

    Density: 1.164 g/cm3

    Solubility: insoluble in water

    Analytical Data

    Appearance: White crystalline powder

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