(-) (S)-3-bromo-2-methylpropanoic acid methyl ester, CAS No. 98190-85-3

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98190-85-3

Catalog No. EBD2205238

CAS 98190-85-3

Name (-) (S)-3-bromo-2-methylpropanoic acid methyl ester

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Basic Information

Synonyms: methyl(S)-3-bromo-2-methylpropionate (-)(S)-3-bromo-2-methylpropanoicacidmethylester (-)-methyl(s)-3-bromo-2-methylpropionate methyl(s)-(-)-3-bromo-2-methylpropionate methyl(s)-(-)-3-bromoisobutyrate (-)-methyl(s)-beta-bromoisobutyrate (s)-(-)-3-bromo-2-methylpropionicacidmethylester (s)-(-)-3-bromoisobutyricacidmethylester methyl(s)-(-)-3-bromo-2-methyl-propionate,97%(99%ee/glc) (-)-methyl(s)-3-bromo-2-methylpropionate,95% (-)-methyl(S)-3-bromo-2-methylpropio-nate ()-Methyl(S)-3-bromo-2-methylpropionate (S)-(-)-3-bromo-2-methylpropionicacid*methylest methyl(2S)-3-bromo-2-methylpropanoate

Molecular Formula: C5H9BrO2

Molecular Weight: 181.03

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

(S)-(-)-3-Bromoisobutyric acid methyl ester is a chiral organic compound characterized by a bromine atom and a methyl ester group attached to an isobutyric acid backbone. Its specific stereochemistry, indicated by the (S)-(-) configuration, makes it a valuable chiral building block in asymmetric synthesis. This compound serves as a versatile precursor in organic synthesis. The bromine atom is a reactive site amenable to nucleophilic substitution reactions, such as cross-couplings, while the ester group can be hydrolyzed to the corresponding acid or reduced to an alcohol. Its primary application lies in the synthesis of more complex chiral molecules, particularly in pharmaceutical research for constructing active pharmaceutical ingredients (APIs) and advanced intermediates that require defined stereocenters. As a liquid, it requires careful handling under inert atmosphere and low-temperature conditions to prevent racemization or decomposition. It is typically used in research and development laboratories focused on medicinal chemistry and fine chemical synthesis.

Physical Properties

Boiling Point: 97.5-98.5 °C/62 mmHg(lit.<WBR>)

Flash Point: 73 °C

Density: 1.422 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.455(lit.)