2'-deoxyguanosine, CAS No. 961-07-9

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961-07-9

Catalog No. EBD3521

CAS 961-07-9

Name 2'-deoxyguanosine

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Basic Information

Synonyms: deoxyguanosine-2' guaninedesoxyriboside 2'-deoxyguanosine 2'-deoxy-d-guanosine a-2'-deoxyguanosine 9-(2'-deoxy-beta-d-ribofuranosyl)guanine 2’-deoxy-guanosin 2[-Deoxyguanosinehemihydrate 2'-deoxyguanosinehemihydrate Deoxyguanosine 2-amino-9-(2-deoxypentofuranosyl)-3,9-dihydro-6H-purin-6-one 2-amino-9-(2-deoxy-alpha-L-erythro-pentofuranosyl)-3,9-dihydro-6H-purin-6-one 2'-Deoxyguanosinemonohydrate 2-amino-9-(2-deoxy-alpha-L-erythro-pentofuranosyl)-3,9-dihydro-6

Molecular Formula: C10H13N5O4

Molecular Weight: 267.24

MDL Number: MFCD00150760

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

2'-Deoxyguanosine is a purine nucleoside consisting of the nucleobase guanine linked to the sugar deoxyribose. It is a fundamental building block of deoxyribonucleic acid (DNA). This compound is a white to off-white crystalline powder that is soluble in water and dimethyl sulfoxide (DMSO). Its primary applications are in life science research and pharmaceutical development. It serves as a critical precursor in the synthesis of nucleoside analogs, which are a major class of antiviral and anticancer drugs (e.g., acyclovir, ganciclovir). It is also widely used as a biochemical reagent in molecular biology for studying DNA replication, repair, and enzymatic processes. Furthermore, it is a key starting material for the production of modified oligonucleotides and probes. As a naturally occurring component of DNA, 2'-deoxyguanosine itself is involved in cellular metabolism. It is also studied in the context of oxidative stress, as its oxidation product, 8-oxo-2'-deoxyguanosine, is a well-known biomarker for DNA damage.

Physical Properties

Melting Point: 300 °C

Boiling Point: 725.475 °C at 760 mmHg

Flash Point: 392.553 °C

Density: 2.085 g/cm3

Solubility: NH4OH 1 M: 50 mg/mL, clear to very faintly turbid, yellow to brown

Refractivity: -42 ° (C=0.2, 1mol/L NaOH)

Storage: Store at RT.