Sotalol hydrochloride, CAS No. 959-24-0

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959-24-0

Catalog No. EBD52017

CAS 959-24-0

Name Sotalol hydrochloride

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Basic Information

Synonyms: (+)-sotalolhydrochloride SotalolHydrochloride 4-(1-hydroxy-2-isopropylaminoethyl)methanesulphonanilidehydrochloride SotalolHCl SolatolHCl 4-(2-isopropylamino-1-hydroxyaethyl)methanesulfonailidhydrochlorid 4’-(1-hydroxy-2-(isopropylamino)ethyl)methanesulfonanilidemonohydrochloride 4’-(1-hydroxy-2-(isopropylamino)ethyl)-methanesulfonanilidmonohydrochlorid isopropylaminohydroxyethylmethanesulfonanilidehydrochloride meadjohnson1999 n-isopropyl-beta-(4-methanesulfonamidophenyl)ethanolaminehydrochloride betapace N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamidehydrochloride 4'-(1-Hydroxy-2-isopropylaminoethyl)methanesulphonanilidehydrochloride

Molecular Formula: C12H21ClN2O3S

Molecular Weight: 308.82

MDL Number: MFCD00242937

Categories: Medicinal Chemistry > APIs and Their Salts > Cardiovascular Drugs Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

Sotalol hydrochloride is a non-selective beta-adrenergic receptor blocker (beta-blocker) with additional Class III antiarrhythmic properties. It exists as a racemic mixture, and its chemical structure is based on a methanesulfonanilide core, distinguishing it from other beta-blockers. Its primary and most significant application is as an active pharmaceutical ingredient (API) for the treatment of cardiac arrhythmias, particularly life-threatening ventricular arrhythmias and the maintenance of normal sinus rhythm in patients with symptomatic atrial fibrillation or flutter. It functions by competitively blocking beta-1 and beta-2 adrenergic receptors (beta-blockade) and by prolonging the cardiac action potential duration and refractory period through potassium channel blockade (Class III effect). Due to its beta-blocking activity, it also has applications in managing hypertension and certain cases of angina pectoris, though its use is primarily focused on arrhythmia management. It is administered orally and requires careful dose titration and monitoring due to its potential to cause proarrhythmia, such as torsades de pointes, especially at higher doses or in patients with electrolyte imbalances.

Physical Properties

Color: white to off-white

Melting Point: 218-220°C

Boiling Point: 443.3 °C at 760 mmHg

Flash Point: 221.9 °C

Solubility: H2O: 20 mg/mL

Analytical Data

Appearance: white crystalline solid