(S)-Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride, CAS No. 958635-15-9

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958635-15-9

Catalog No. EBD2212404

CAS 958635-15-9

Name (S)-Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one hydrochloride

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Basic Information

Synonyms: (S)-Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-onehydrochloride (s)-hexahydro-oxazolo[3,4-a]pyrazin-3-onehcl (s)-hexahydro-oxazolo[3,4-a]pyrazin-3-onehydrochloride (8as)-hexahydro-1h-[1,3]oxazolo[3,4-a]piperazin-3-onehydrochloride 3h-oxazolo[3,4-a]pyrazin-3-one,hexahydro-,hydrochloride,(8as)- (8aS)-1,5,6,7,8,8a-hexahydrooxazolo[3,4-a]pyrazin-3-onehydrochloride (8aS)-Hex 3H-Oxazol T56ANVOGMTJ&&SFormHCl

Molecular Formula: C6H11ClN2O2

Molecular Weight: 178.62

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics

Product Description:

(S)-Hexahydro-oxazolo[3,4-a]pyrazin-3-one hydrochloride is a chiral, bicyclic heterocyclic compound featuring an oxazolidinone ring fused to a piperazine ring. It serves as a key synthetic intermediate and a versatile scaffold in medicinal chemistry, particularly for the construction of peptide-like structures and constrained peptidomimetics. Its primary application is in the research and development of pharmaceutical agents. The rigid, polycyclic structure is valuable for mimicking peptide secondary structures, which can enhance metabolic stability and receptor selectivity. This scaffold is frequently utilized in the synthesis of protease inhibitors and other bioactive molecules targeting various diseases. The (S)-enantiomer is often specifically required for optimal biological activity. As a building block, it enables the introduction of complex, three-dimensional pharmacophores into drug candidates. Its use is prominent in the discovery of novel therapeutic compounds, especially within the fields of oncology and infectious diseases, where modulating protein-protein interactions is crucial.

Physical Properties

Boiling Point: 378.1°C at 760 mmHg

Flash Point: 182.5°C