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    953411-16-0

    Catalog No. EBD1995030

    CAS 953411-16-0

    Name 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-3-amine

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    Basic Information

    Synonyms: 1H-Indazol-3-amine,5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-3-amine

    Molecular Formula: C13H18BN3O2

    Molecular Weight: 259.11

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

    Product Description:
    5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-3-amine is a heterocyclic organic compound featuring an indazole core substituted with an amine group at the 3-position and a pinacol boronate ester at the 5-position. This structure makes it a versatile and valuable synthetic intermediate. Its primary application is in medicinal chemistry and pharmaceutical research as a key building block for the synthesis of more complex molecules. The presence of both the amine and the boronate ester functional groups allows it to participate in diverse cross-coupling reactions, such as Suzuki-Miyaura couplings, and other derivatization reactions. This enables the efficient construction of novel indazole-based compounds, which are privileged scaffolds in drug discovery, particularly for developing kinase inhibitors and other biologically active agents targeting various diseases. As a boronic ester derivative, it is a stable and convenient precursor to the corresponding boronic acid, facilitating its handling and storage in synthetic workflows. It is primarily used in research and development settings for constructing targeted molecular libraries.
    Physical Properties
    mg g kg ml l t