(2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol, CAS No. 95094-00-1

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95094-00-1

Catalog No. EBD137073

CAS 95094-00-1

Name (2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol

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Basic Information

Synonyms: (-)-1-(9h-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol (s)-(-)-carvedilol 2-propanol,1-(9h-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-,(2s)- 2-propanol,1-(9h-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-,(s)- (2s)-1-(9h-carbazole-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propane-2-ol (s)-1-(9h-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol [s,(-)]-1-(9h-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol carvedilols-isomer (2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol

Molecular Formula: C24H26N2O4

Molecular Weight: 406.47

Categories: Medicinal Chemistry > APIs and Their Salts > Cardiovascular Drugs Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

(S)-(-)-Carvedilol is the (S)-enantiomer of carvedilol, a non-selective beta-adrenergic blocker with additional alpha-1 blocking activity. It is a white to off-white crystalline powder. This specific stereoisomer is primarily responsible for the beta-blocking activity of the racemic drug. (S)-(-)-Carvedilol is the active pharmaceutical ingredient (API) in the formulation of the drug Carvedilol, which is widely used in the treatment of cardiovascular diseases. Its primary applications include the management of hypertension, mild to severe chronic heart failure, and left ventricular dysfunction following myocardial infarction. The drug works by blocking beta-1, beta-2, and alpha-1 adrenergic receptors, leading to vasodilation and reduced cardiac workload. While the racemic mixture is commonly used, the (S)-enantiomer is the therapeutically active form for beta-blockade. It is a critical component in chiral drug development and manufacturing, ensuring product efficacy and meeting regulatory standards for enantiomeric purity.

Physical Properties

Melting Point: 114-115 °C

Boiling Point: 655.2 °C at 760 mmHg

Flash Point: 350.1 °C

Density: 1.25 g/cm3

Analytical Data

Appearance: Colourless crystalline solid