N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]thiourea, with CAS number 949480-57-3, is a synthetic small molecule characterized by a thiourea core linking a 3,5-bis(trifluoromethyl)phenyl group to a chiral (1S,2R)-2-hydroxyindane moiety. This compound is a well-known and potent ligand for the von Hippel-Lindau (VHL) E3 ubiquitin ligase. It serves as a critical component in the field of targeted protein degradation, specifically in the design of Proteolysis-Targeting Chimeras (PROTACs). By functioning as a high-affinity VHL binder, it enables the recruitment of the VHL E3 ligase complex to a protein of interest, leading to its ubiquitination and subsequent degradation by the proteasome. It is frequently used as a starting point or a key building block for synthesizing VHL-based PROTAC molecules. As a research tool, it is essential for studying PROTAC technology, validating degradation strategies, and developing novel therapeutics for diseases driven by undruggable proteins. Its defined stereochemistry is crucial for its binding affinity and specificity.