(4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid, CAS No. 949023-16-9

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949023-16-9

Catalog No. EBD36807

CAS 949023-16-9

Name (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid

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Basic Information

Synonyms: (4s,5r)-3-benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylicacid paclitaxelsidechainacid (4s,5r)-2-(4-methoxyphenyl)-n-benzoyl-4-phenyloxazolidine-5-carboxylicacid 3-{[2-(4-methoxyphenyl)phenyl]carbonyl}-4-phenyl-1,3-oxazolidine-5-carboxylicacid (4s,5r)-3-benzoyl-2-(4-anisyl)-4-phenyl-5-oxazolidinecarboxylicacid (4s,5r)-3-benzoyl-2-(4-anisyl)-4-phenyl-5-oxazolidinecarboxylic 5-oxazolidinecarboxylicacid,3-benzoyl-2-(4-methoxyphenyl)-4-phenyl-,(4s,5r)- (4S,5R)-3-benzoyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylicacid (2R,4S,5R)-3-Benzoyl-2-(4-Methoxyphenyl)-4-Phenyl-5-OxazolidinecarboxylicAcid (2R,4S,5R)-2-(4-methoxyphenyl)-N-benzoyl-4-phenyloxazolidine-5-carboxylicacid (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylicacid (4S,5R)-3-benzoyl-2-(4-methoxyph

Molecular Formula: C24H21NO5

Molecular Weight: 403.43

MDL Number: MFCD11617943

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents

Product Description:

The compound with CAS 949023-16-9 is a key chiral intermediate, specifically the side chain of the potent anticancer drug Paclitaxel (Taxol). Its chemical structure is (2R,3S)-3-Phenylisoserine, which is a crucial fragment for constructing the complex taxane core of Paclitaxel. This intermediate is essential for the semi-synthetic production of Paclitaxel and its derivatives. Its primary and definitive application is in the pharmaceutical industry for the synthesis of Paclitaxel, a microtubule-stabilizing agent widely used in the treatment of various cancers, including ovarian, breast, and lung cancers. The synthesis of this side chain and its subsequent coupling to a baccatin III core represent a critical step in the commercial manufacturing process, enabling a more reliable supply compared to extraction from the yew tree. As a specialized chiral building block with a very specific and high-value end-use, it is not considered a general-purpose synthetic reagent. Its development and production are tightly focused on supporting the anticancer drug supply chain, making it a quintessential pharmaceutical intermediate.

Physical Properties

Boiling Point: 642.269 °C at 760 mmHg

Flash Point: 342.232 °C

Density: 1.291 g/cm3