2-Bromo-5-fluorobenzaldehyde, CAS No. 94569-84-3

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94569-84-3

Catalog No. EBD51711

CAS 94569-84-3

Name 2-Bromo-5-fluorobenzaldehyde

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Basic Information

Synonyms: 5-fluoro-2-bromobenzaldehyde 2-bromo-5-fluorobenzaldhyde 2-bromo-5-fluorobenzaldehyde,98% benzaldehyde,2-bromo-5-fluoro- 2-bromo-5-fluorobenzaldehyde,95+% 2-bromo-5-fluorobenzaldehyde96% 2-Bromo-5-fluorobenzaldehyde

Molecular Formula: C7H4BrFO

Molecular Weight: 203.01

MDL Number: MFCD00142872

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

2-Bromo-5-fluorobenzaldehyde is a disubstituted benzaldehyde featuring a bromine atom at the 2-position and a fluorine atom at the 5-position on the aromatic ring. This compound serves as a versatile bifunctional building block in organic synthesis, where the aldehyde group enables condensation and reductive amination reactions, while the bromine substituent allows for cross-coupling transformations such as Suzuki, Heck, or Sonogashira reactions. The fluorine atom further modulates the electronic properties and metabolic stability of derived molecules. In pharmaceutical research, this compound is primarily utilized as a key intermediate for constructing small-molecule drug candidates, particularly in the development of kinase inhibitors, G-protein-coupled receptor (GPCR) modulators, and other bioactive heterocyclic compounds. Its halogenated pattern makes it valuable for structure-activity relationship (SAR) studies in medicinal chemistry programs targeting oncology, inflammation, and central nervous system disorders. The compound is typically handled under standard laboratory conditions with appropriate ventilation due to its irritant properties.

Physical Properties

Melting Point: 51-56 °C(lit.)

Boiling Point: 225.8 °C at 760 mmHg

Flash Point: 87 °C

Density: 1.67 g/cm3

Storage: 2-8°C