3-Bromoquinolin-2(1H)-one, CAS No. 939-16-2

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939-16-2

Catalog No. EBD258923

CAS 939-16-2

Name 3-Bromoquinolin-2(1H)-one

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Basic Information

Synonyms: 3-bromo-1h-quinolin-2-one 3-bromocarbostyril 2(1h)-quinolinone,3-bromo- 3-bromo-2-quinolinol(saltdata:free) 3-bromo-1,2-dihydroquinolin-2-one 3-bromo-2-hydroxyquinoline 3-bromo-2-quinolinol 3-bromoquinolin-2(1H)-one

Molecular Formula: C9H6BrNO

Molecular Weight: 224.05

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

3-Bromoquinolin-2(1H)-one is a heterocyclic organic compound featuring a quinolinone core structure substituted with a bromine atom at the 3-position. It serves as a versatile and valuable synthetic building block in medicinal chemistry and organic synthesis. Its primary application is as a key intermediate in the synthesis of various biologically active molecules, particularly in the development of pharmaceutical candidates. The bromine atom at the 3-position is a reactive site amenable to cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), allowing for the introduction of diverse substituents to explore structure-activity relationships. This scaffold is frequently utilized in the research and development of compounds targeting kinases, receptors, and enzymes. As a halogenated heterocycle, it is a common starting material for constructing more complex quinoline and quinazoline derivatives, which are privileged structures in drug discovery for their wide range of therapeutic activities.

Physical Properties

Melting Point: 260-265 °C

Boiling Point: 395.2 °C at 760 mmHg

Flash Point: 192.8 °C

Density: 1.666 g/cm3