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    937049-58-6

    Catalog No. EBD753421

    CAS 937049-58-6

    Name 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole

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    Basic Information

    Synonyms: 6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indazole 1h-indazole,6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

    Molecular Formula: C13H17BN2O2

    Molecular Weight: 244.1

    MDL Number: MFCD07368067

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

    Product Description:
    1H-Indazole-6-boronic acid pinacol ester is a heterocyclic organoboron compound featuring a boronic ester group attached to the 6-position of the 1H-indazole core. This structure makes it a versatile and valuable building block in modern synthetic chemistry, particularly in cross-coupling reactions such as the Suzuki-Miyaura reaction. Its primary application is as a key intermediate in the pharmaceutical industry for the synthesis of various drug candidates and active pharmaceutical ingredients (APIs). The indazole scaffold is a privileged structure in medicinal chemistry, found in compounds targeting a range of therapeutic areas, including oncology and central nervous system disorders. The boronic ester functionality allows for efficient, palladium-catalyzed coupling with aryl or heteroaryl halides, enabling the rapid construction of complex, drug-like molecules. As a protected form of the corresponding boronic acid, this pinacol ester offers improved stability and handling characteristics compared to the free acid, making it a preferred reagent for storage and use in multi-step synthetic sequences. It is a standard item in catalogs of fine chemicals and building blocks for drug discovery.
    Physical Properties

    Melting Point: 134-139 °C

    Boiling Point: 404.1°C at 760 mmHg

    Flash Point: 198.2°C

    Density: 1.15g/cm3

    mg g kg ml l t