Sacubitril/valsartan (LCZ696), CAS No. 936623-90-4

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936623-90-4

Catalog No. EBD3327517

CAS 936623-90-4

Name Sacubitril/valsartan (LCZ696)

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Basic Information

Synonyms: Sacubitril/valsartan (LCZ696) LCZ696 Entresto L-Valine,N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-,compd.withα-ethyl(αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1'-biphenyl]-4-pentanoate,sodiumsalt,hydrate(2:2:6:5) trisodium[3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3-methyl-2-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4-ylmethyl}amino)butyrate]hemipentahydrate trisodium3-((1S,3R)-1-(biphenyl-4-ylmethyl)-3-(ethoxycarbonyl)butylcarbamoyl)propionate(S)-3-methyl-2-(pentanoyl-(2-(tetrazol-1-at-5-yl)biphenyl-4'-ylmethyl)amino)butyratehemipentahydrate Sacubitril/valsartan (LCZ696)

Molecular Formula: C48H57N6NaO9

Molecular Weight: 884.99

Categories: Medicinal Chemistry > APIs and Their Salts > Cardiovascular Drugs Medicinal Chemistry > APIs and Their Salts > Other Drugs

Product Description:

Sacubitril/valsartan (LCZ696) is a supramolecular sodium salt complex co-crystal composed of the neprilysin inhibitor prodrug sacubitril (AHU377) and the angiotensin II receptor blocker valsartan in a 1:1 molar ratio. This dual-acting agent represents a novel class of cardiovascular therapeutics. Its primary and well-defined application is in the treatment of chronic heart failure with reduced ejection fraction (HFrEF). The co-crystal formulation allows for the simultaneous inhibition of neprilysin (via the active metabolite of sacubitril, LBQ657) and blockade of the angiotensin II type 1 receptor (by valsartan). This dual mechanism promotes beneficial vasodilation, natriuresis, and counteracts maladaptive neurohormonal activation, leading to reduced cardiovascular mortality and hospitalization rates. Marketed under the brand name Entresto, it is a finished pharmaceutical product and a key active pharmaceutical ingredient (API). Its classification is firmly within the cardiovascular drug category, with no significant utility as a general-purpose chemical reagent or synthesis building block.

Physical Properties

Boiling Point: 637.097 °C at 760 mmHg

Flash Point: 339.104 °C

Density: 1.391 g/cm3

Solubility: DMSO: 18 mg/mL

Analytical Data

Appearance: Tan solid