Cilazapril monohydrate, CAS No. 92077-78-6

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

92077-78-6

Catalog No. EBD2321386

CAS 92077-78-6

Name Cilazapril monohydrate

Get Quote

Basic Information

Synonyms: Cilazapril Monohydrate 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid,9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-,hydrate Cilazaprilmonohydrate 6h-pyridazino(1,2-a)(1,2)diazepine-1-carboxylicacid,octahydro-9-((1-(ethoxyca hydrate,(1s-(1-alpha,9-alpha(r*)))-rbonyl)-3-phenylpropyl)amino)-10-oxo ro31-2848monohydrate cilazaprilepc( cilazaprilepc(crmstandard) cilazapril 1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylicacid9-ethylestermonohydrate 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylicacid,9-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)octahydro-10-oxo-,monohydrate,(1S-(1alpha,9alpha(R*)))- 6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylicacid,octahydro-9-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-10-oxo-,hydrate,(1S-(1-alpha,9-alpha(R*)))-

Molecular Formula: C22H33N3O6

Molecular Weight: 435.51

Categories: Medicinal Chemistry > APIs and Their Salts > Cardiovascular Drugs Medicinal Chemistry > APIs and Their Salts > Other Drugs

Product Description:

Cilazapril monohydrate is the monohydrate form of cilazapril, a potent and long-acting angiotensin-converting enzyme (ACE) inhibitor. It is a prodrug that is hydrolyzed in vivo to its active diacid metabolite, cilazaprilat. The compound is a white to off-white crystalline powder. Cilazapril is primarily used as an active pharmaceutical ingredient (API) in the treatment of hypertension (high blood pressure) and congestive heart failure. It works by inhibiting the ACE, which prevents the conversion of angiotensin I to the potent vasoconstrictor angiotensin II, leading to vasodilation and reduced blood pressure. It also decreases aldosterone secretion, which helps reduce sodium and water retention. This API is typically formulated into oral dosage forms, such as tablets. As a pharmaceutical substance, it is subject to strict quality control standards, including specifications for purity, related substances (impurities), and the monohydrate form. Its development and use are governed by pharmacopoeial monographs (e.g., European Pharmacopoeia).

Physical Properties

Boiling Point: 598.1 °C at 760 mmHg

Flash Point: 315.5 °C