(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene, CAS No. 915095-94-2

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915095-94-2

Catalog No. EBD752480

CAS 915095-94-2

Name (S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene

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Basic Information

Synonyms: (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan Empagliflozinintermediate EmpagliflozinII EmpagliflozinIntermediate1 (S)-3-(4-(2-chloro-5-iodobenzyl)phenoxy)-tetrahydrofuran (3s)-3-(4-((2-chloro-5-iodophenyl)methyl)phenoxy)tetrahydro-furan (S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene (S)-3-[4-(5-iodo-2-chloro-benzyl)-phenoxy]-tetrahydrofuran

Molecular Formula: C17H16ClIO2

Molecular Weight: 414.67

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents

Product Description:

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran is a key chiral intermediate in the synthesis of the anticancer drug Alpelisib (BYL719). Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor specifically targeting the PIK3CA gene mutation, which is found in various cancers, including breast cancer. This compound is a critical building block for constructing the core structure of the drug molecule. The primary and well-defined application of this chemical is in the pharmaceutical manufacturing process of Alpelisib. Its structure contains a tetrahydrofuran ring and a substituted biphenyl moiety, which are essential pharmacophoric elements for the drug's activity. As a high-value synthetic intermediate, it is not a general-purpose building block but is specifically designed and utilized for this targeted therapeutic agent.

Physical Properties