Noscapine hydrochloride, CAS No. 912-60-7

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912-60-7

Catalog No. EBD12529

CAS 912-60-7

Name Noscapine hydrochloride

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Basic Information

Synonyms: narcotinehydrochloride ,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(s-(r*,s*))- 1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1 1-alpha-narcotinehydrochloride capvalhydrochloride coscopinhydrochloride noscapinehydrochloridehydrate Noscapinehydrochloride CCRIS8985 Capval Coscotabshydrochloride DifmetusKapseln GermoseNoscapine Key-tusscapinehydrochloride Longatin Lyobexretard Methoxyhydrastinehydrochloride NSC5366hydrochloride Narcomprenhydrochloride Narcosinehydrochloride Narcotussin Nectadonhydrochloride Nipaxon NoscapineHCl Opianhydrochloride Opianinehydrochloride Stilco Teletux Terbenolhydrochloride Tucotine Tulisan Tusscapine TussicureP UNII-TTN62ITH9I Vadebexhydrochloride 1(3H)-Isobenzofuranone,6,7-dimethoxy-3-((5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(3S)- 1(3H)Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro

Molecular Formula: C22H24ClNO7

Molecular Weight: 449.88

Categories: Medicinal Chemistry > APIs and Their Salts > Respiratory Drugs Medicinal Chemistry > Biochemicals and Life Science Reagents > Phytochemicals and Natural Products

Product Description:

Noscapine hydrochloride is the hydrochloride salt of noscapine, a naturally occurring phthalideisoquinoline alkaloid primarily derived from the opium poppy (*Papaver somniferum*). It is a white to off-white crystalline powder with the molecular formula C22H23NO7·HCl. Historically, noscapine has been widely used as an antitussive (cough suppressant) agent. Its mechanism of action involves central suppression of the cough reflex, acting on the cough center in the medulla oblongata. Unlike codeine, it has minimal analgesic and sedative effects and a low potential for addiction, making it a common non-opioid cough medication in many over-the-counter and prescription formulations. Beyond its established use in respiratory medicine, noscapine has been investigated for other pharmacological activities, most notably for its potential as an anticancer agent. Research indicates it can bind to tubulin, inhibit microtubule dynamics, and induce apoptosis in various cancer cell lines. It is also studied for its anti-inflammatory and neuroprotective properties.

Physical Properties

Melting Point: 221-223 °C(lit.)

Boiling Point: 565.3°Cat760mmHg

Flash Point: 295.7°C

Density: 1.332g/cm3

Storage: 2-8°C