5-Bromo-2-methyl-3-nitropyridine, CAS No. 911434-05-4

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911434-05-4

Catalog No. EBD31579

CAS 911434-05-4

Name 5-Bromo-2-methyl-3-nitropyridine

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Basic Information

Synonyms: 5-Bromo-2-methyl-3-nitropyridine 5-bromo-3-nitropicoline 5-bromo-2-methyl-3-nitrop... 5-bromo-3-nitro-2-picoline 5-bromo-2-methyl-3-n pyridine,5-bromo-2-methyl-3-nitro- 5-Bromo-3-nitro-α-picoline T6NJB1CNWEE

Molecular Formula: C6H5BrN2O2

Molecular Weight: 217.02

MDL Number: MFCD09031419

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

Product Description:

5-Bromo-2-methyl-3-nitropyridine is a halogenated and nitrated pyridine derivative. It serves as a versatile and important heterocyclic building block in organic synthesis, particularly in medicinal chemistry. The presence of both bromine and nitro groups on the pyridine ring makes it a valuable intermediate for further functionalization through cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and reduction reactions. Its primary application is in the research and development of pharmaceutical compounds. This compound is specifically cited as a key intermediate in the synthesis of various biologically active molecules, including kinase inhibitors and other potential therapeutic agents targeting diverse disease pathways. The 2-methyl-3-nitropyridine scaffold is a common motif in drug discovery. As a synthetic intermediate, it is typically handled under standard laboratory conditions. Precautions should be taken due to the potential irritant properties common to nitroaromatic and halogenated compounds.

Physical Properties

Boiling Point: 252.6 °C at 760 mmHg

Flash Point: 106.6 °C

Density: 1.709 g/cm3