2-phenylaniline, CAS No. 90-41-5

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90-41-5

Catalog No. EBD22907

CAS 90-41-5

Name 2-phenylaniline

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Basic Information

Synonyms: 2-phenylaniline 2-Aminobiphenyl Aminobiphenyl 2-Biphenylylamine~2-Phenylaniline 2-aminodiphenyl 2-Aminobiphenyl,(2-Biphenylamine 2-Phenylanili 2-Biphenylamine 2-amino-1,1’-biphenyl 2-aminobifenyl 2-aminobiphenyl(forsugardetermination) 2-phenylbenzenamine biphenyl,2-amino- nci-c50282 ortho-amino-biphenyl 2-phenylanilin o-phenylaniline (1,1'-biphenyl)-2-amine

Molecular Formula: C12H11N

Molecular Weight: 169.22

MDL Number: MFCD00007701

Product Description:

2-Phenylaniline is an aromatic amine consisting of a biphenyl core with a primary amino group at the ortho position. It serves as a key building block in medicinal chemistry, particularly for constructing heterocyclic systems and bioactive molecules. Its structure is frequently employed in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs), such as fenamic acid derivatives, and other pharmaceutical agents targeting the central nervous system or inflammation pathways. As a versatile synthetic intermediate, 2-aminobiphenyl is widely used in cross-coupling reactions, including Buchwald-Hartwig amination and direct C-H functionalization, to introduce biphenylamine motifs into complex organic frameworks. It also acts as a precursor for dyes, pigments, and organic electronic materials. Due to its dual role as a drug fragment and a general-purpose amine building block, it is classified under both pharmaceutical intermediates and synthetic chemistry.

Physical Properties

Melting Point: 47-50 °C(lit.)

Boiling Point: 299 °C(lit.)

Flash Point: 153 °C

Density: 5.8 (vs air)

Solubility: Insoluble in water

Refractivity: 1.613-1.615

Analytical Data

Appearance: colourless to purple crystalline solid