4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)morpholine, CAS No. 888721-86-6

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888721-86-6

Catalog No. EBD2046481

CAS 888721-86-6

Name 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)morpholine

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Basic Information

Synonyms: 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]morpholine 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)morpholine 2-morpholinopyridine-4-boronicacid,pinacolester 2-morpholinopyridin-4-ylboronicacidpinacolester morpholine,4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]- [2-(morpholin-4-yl)pyridin-4-yl]boronicacid 2-morpholinopyridine-4-boronicacid,pinacolesteraldrichcpr

Molecular Formula: C15H23BN2O3

Molecular Weight: 290.17

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

Product Description:

2-Morpholinopyridin-4-ylboronic acid pinacol ester is a heterocyclic organoboron compound featuring a pyridine core substituted with a morpholine group at the 2-position and a boronic acid pinacol ester at the 4-position. This structure combines a nitrogen-containing heterocycle with a protected boronic acid functional group, making it a versatile building block. Its primary application is in medicinal chemistry as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs). The boronic ester moiety is crucial for Suzuki-Miyaura cross-coupling reactions, a widely used method for constructing biaryl and heterobiaryl bonds. This enables the efficient introduction of the 2-morpholinopyridine fragment into more complex molecular architectures, which are often explored for their biological activity in drug discovery programs targeting various diseases. As a protected boronic acid derivative, it offers improved stability and handling compared to the free boronic acid. Its utility extends beyond pharmaceutical synthesis into general organic synthesis and materials science research where the construction of specific heterocyclic systems is required.

Physical Properties

Boiling Point: 450.1 °C at 760 mmHg

Flash Point: 226 °C

Density: 1.13 g/cm3