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    88763-76-2

    Catalog No. EBD16745

    CAS 88763-76-2

    Name (R)-3-Aminopiperidine-2-one

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    Basic Information

    Synonyms: (3R)-2-oxopiperidin-3-aminiumchloride (3R)-3-Aminopiperidin-2-onehydrochloride(1:1) 2-Piperidinone,3-amino-,(3R)-,hydrochloride(1:1) (R)-3-AMINOPIPERIDINE-2-ONE (r)-3-aminopiperidine-2-onehydrochloride (r)-3-amino-2-piperidinone

    Molecular Formula: C5H10N2O

    Molecular Weight: 114.15

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (R)-3-Amino-2-piperidinone is a chiral heterocyclic compound featuring a piperidinone ring core with an amino group at the 3-position. It is a white to off-white crystalline powder. This compound is a key chiral building block in organic synthesis, particularly valued for its structural motif found in various biologically active molecules. Its primary and most significant application is as a crucial intermediate in the pharmaceutical industry. It serves as a key chiral synthon for the synthesis of several important drugs. Most notably, it is a fundamental building block in the production of the anticoagulant drug Apixaban (Eliquis®), a direct Factor Xa inhibitor. The (R)-configuration of the amino group is essential for the biological activity of the final API. As a versatile chiral amine, it is also employed in the synthesis of other pharmacologically active compounds and novel chemical entities. Its stability and reactivity make it a valuable reagent in medicinal chemistry research for constructing complex nitrogen-containing heterocycles.
    Physical Properties

    Boiling Point: 307.5°C at 760 mmHg

    Flash Point: 139.8°C

    mg g kg ml l t