6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid, CAS No. 88574-06-5

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88574-06-5

Catalog No. EBD490924

CAS 88574-06-5

Name 6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid

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Basic Information

Synonyms: fmoc-nh-(ch2)5-cooh fmoc-aminocaproicacid fmoc-ahx(6)-oh fmoc-acp-oh fmoc-acp(6)-oh fmoc-6-aca-oh fmoc-6-ahx-oh fmoc-6-aminocaproicacid fmoc-6-aminohexanoicacid

Molecular Formula: C21H23NO4

Molecular Weight: 353.41

MDL Number: MFCD00077045

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Peptides and Peptidomimetics Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

N-Fmoc-6-aminohexanoic acid is a protected amino acid derivative featuring a 6-aminohexanoic acid (6-Ahx) backbone with an N-terminal 9-fluorenylmethoxycarbonyl (Fmoc) protecting group. It is a white to off-white crystalline powder with a molecular formula of C₂₁H₂₃NO₄. This compound is a crucial building block in solid-phase peptide synthesis (SPPS) using the Fmoc strategy. The 6-Ahx spacer, also known as an aminocaproic acid linker, is widely incorporated into synthetic peptides to enhance solubility, increase conformational flexibility, and provide a spacer between functional domains. Its primary application is in the research and development of therapeutic peptides, peptide-drug conjugates, and as a component in the synthesis of peptide-based materials and bioconjugates. As a specialty amino acid derivative, it is a fundamental reagent in bioconjugate chemistry and life sciences research. It is commercially available from major suppliers of peptide synthesis reagents and biochemicals.

Physical Properties

Boiling Point: 582.7 °C at 760 mmHg

Flash Point: 306.2 °C

Density: 1.21 g/cm3

Storage: 2-8°C