1H-Indazol-4-ylboronic acid pinacol ester, CAS No. 885618-33-7

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885618-33-7

Catalog No. EBD40495

CAS 885618-33-7

Name 1H-Indazol-4-ylboronic acid pinacol ester

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Basic Information

Synonyms: 1H-Indazol-4-ylboronicacidpinacolester 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 1H-Indazo 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol 1H-Indazole-4-boronicacidpinacolester 4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indazole 1h-indazole,4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- indazole-4-boronicacidp... 2-dioxaborolan-2-yl)-1h-indazole 3-hydroxy-2,3-dimethylbutan-2-ylhydrogen1h-indazol-4-ylboronate 1h-indazol-4-boronicacidpinacolester Indazole-4-boronicacidpinacolester

Molecular Formula: C13H17BN2O2

Molecular Weight: 244.1

MDL Number: MFCD08059267

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

Product Description:

1H-Indazole-4-boronic acid pinacol ester is a heterocyclic organoboron compound featuring an indazole core functionalized with a boronic ester group at the 4-position. The pinacol ester protects the boronic acid, enhancing its stability and solubility for handling and storage in organic synthesis. This compound serves as a key synthetic intermediate, particularly in the pharmaceutical industry. Its primary application is in Suzuki-Miyaura cross-coupling reactions, a widely used method for forming carbon-carbon bonds. The boronic ester moiety readily couples with various aryl or heteroaryl halides, enabling the efficient construction of complex, functionalized indazole derivatives. These indazole scaffolds are of high interest in medicinal chemistry for the discovery and development of new drug candidates targeting a range of diseases. As a protected boronic acid derivative of a privileged heterocycle, it is a valuable building block for research and development. It is commercially available from suppliers specializing in advanced pharmaceutical intermediates and organoboron reagents for synthesis.

Physical Properties

Boiling Point: 404.123 °C at 760 mmHg

Flash Point: 198.207 °C

Density: 1.154 g/cm3