L-valine allyl ester p-toluenesulfonate, CAS No. 88224-02-6

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88224-02-6

Catalog No. EBD882105

CAS 88224-02-6

Name L-valine allyl ester p-toluenesulfonate

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Basic Information

Synonyms: L-valineallylestertoluene-4-sulfonate L-Valineallylesterp-toluenesulfonatesalt (2S)-3-methyl-1-oxo-1-(prop-2-en-1-yloxy)butan-2-aminium4-methylbenzenesulfonate L-valineallylesterp-toluenesulfonate L-valineallylesterp-tosylate L-Valin-allylester-hydro-p-toluolsulfonat l-valineallylester4-toluenesulfonatesalt h-val-allylesterp-tosylate h-val-allylestertos-oh h-val-oalltosoh h-val-oaltos-oh valine-allylesterp-tosylate

Molecular Formula: C15H23NO5S

Molecular Weight: 329.41

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

L-Valine allyl ester p-toluenesulfonate is a white to off-white crystalline powder. It is a derivative of the essential amino acid L-valine, where the carboxylic acid group is protected as an allyl ester and the amino group is in the form of a p-toluenesulfonate salt. This specific structure combines a chiral amino acid backbone with a versatile allyl protecting group. This compound is primarily used as a key chiral building block in the synthesis of complex molecules, particularly in the pharmaceutical industry. The allyl ester group serves as a common protecting group for carboxylic acids in peptide synthesis and can be selectively removed under mild conditions (e.g., using palladium catalysts) without affecting other sensitive functional groups. Its main application is as a crucial intermediate in the synthesis of various peptide-based drugs and bioactive compounds, leveraging the chirality of L-valine to impart specific biological activity. The p-toluenesulfonate salt form enhances the compound's crystallinity and stability, making it suitable for handling and storage in research and development settings. It is a valuable reagent for medicinal chemists and peptide scientists focused on developing new therapeutic agents.

Physical Properties

Melting Point: 117-120 °C

Boiling Point: 200.1 °C at 760 mmHg

Flash Point: 70.7 °C

Storage: 2-8°C