1-Chloro-2-(trifluoromethyl)benzene, CAS No. 88-16-4

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

88-16-4

Catalog No. EBD53964

CAS 88-16-4

Name 1-Chloro-2-(trifluoromethyl)benzene

Get Quote

Basic Information

Synonyms: o-chloro-alpha,alpha,alpha-trifluorotoluene 2-chloro(trifluoromethyl)benzene o-(trifluoromethyl)chlorobenzene o-trifluoromethylphenylchloride Chlorobenzotrifluoride 2-chloro-α,α,α-trifluorotoluene O-Chlorobenzotrifluoride 2-Chlorobenzotrifluoride 2-Chloro-alpha,alpha,alpha-trifluorotoluene

Molecular Formula: C7H4ClF3

Molecular Weight: 180.55

MDL Number: MFCD00000561

Product Description:

1-Chloro-2-(trifluoromethyl)benzene is an aromatic organic compound featuring a chlorine atom and a trifluoromethyl group at the ortho position on a benzene ring. Its molecular formula is C7H4ClF3, and it is a colorless to pale yellow liquid with a characteristic odor. This compound serves as a key building block in organic synthesis, particularly for introducing the trifluoromethylphenyl moiety into target molecules. Its primary application lies in the pharmaceutical industry as a crucial intermediate for synthesizing active pharmaceutical ingredients (APIs), especially those targeting central nervous system disorders and anti-inflammatory drugs. The trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable in drug design. Additionally, it is used in the production of agrochemicals, such as herbicides and fungicides, where the halogenated aromatic core contributes to biological activity. As a versatile synthetic building block, it participates in cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic aromatic substitution to construct complex molecular architectures. Due to its reactivity and stability, it is widely employed in medicinal chemistry and material science for developing fluorinated compounds with improved pharmacokinetic properties. Proper handling is required due to its irritant nature and potential environmental persistence.

Physical Properties

Melting Point: -7.4 °C

Boiling Point: 152 °C(lit.)

Flash Point: 44 °C

Density: 1.379 g/mL at 25 °C(lit.)

Solubility: <0.1 g/100 mL at 19.5 °C in water

Refractivity: n20/D 1.456(lit.)

Storage: Flammables area

Safety Information

Packing Level: III

Hazard Category: 3

Transport Codes: 2234

Analytical Data

Appearance: clear colourless to light yellow liquid