R-3-CBZ-AMINO PYRROLIDINE-HCl, CAS No. 879275-77-1

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879275-77-1

Catalog No. EBD48171

CAS 879275-77-1

Name R-3-CBZ-AMINO PYRROLIDINE-HCl

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Basic Information

Synonyms: R-3-CBZ-AMINOPYRROLIDINE-HCl benzylN-[(3R)-pyrrolidin-3-yl]carbamate Benzyl(3R)-pyrrolidin-3-ylcarbamate Carbamicacid,N-[(3R)-3-pyrrolidinyl]-,phenylmethylester (R)-3-N-Cbz-Aminopyrrolidine (r)-benzylpyrrolidin-3-ylcarbamate carbamicacid,n-(3r)-3-pyrrolidinyl-,phenylmethylester

Molecular Formula: C12H17ClN2O2

Molecular Weight: 256.73

MDL Number: MFCD04115316

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

This compound is a chiral, N-protected pyrrolidine derivative. It serves as a crucial chiral building block in pharmaceutical synthesis, particularly for the construction of bioactive molecules containing the pyrrolidine scaffold. The Cbz (carboxybenzyl) group acts as a protecting group for the secondary amine, allowing for selective deprotection and further functionalization. This compound is extensively used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates. Its primary application lies in medicinal chemistry research and development, where it is employed to introduce the (R)-3-aminopyrrolidine moiety into target structures. This scaffold is found in various therapeutic agents, including protease inhibitors and other enzyme-targeting drugs. As a versatile synthetic intermediate, it is valued for its defined stereochemistry and compatibility with standard peptide coupling and deprotection conditions. It is commercially available from suppliers specializing in fine chemicals and advanced pharmaceutical intermediates.

Physical Properties

Boiling Point: 382.5 °C at 760 mmHg

Flash Point: 185.1 °C

Density: 1.16 g/cm3