Fmoc-D-Ser-OMe, with CAS number 874817-14-8, is a protected derivative of the non-essential amino acid D-serine. Its chemical structure features an Fmoc (9-fluorenylmethoxycarbonyl) group protecting the amine functionality and a methyl ester protecting the carboxylic acid group. This specific configuration renders it a chiral, orthogonally protected building block. This compound is primarily employed as a key intermediate in solid-phase peptide synthesis (SPPS) and solution-phase peptide chemistry. The Fmoc group is widely used as a base-labile protecting group for amines, allowing for sequential peptide chain elongation. The D-serine residue is incorporated into peptides to modulate their biological activity, stability against proteolytic degradation, and conformational properties. It is crucial for the synthesis of peptidomimetics and biologically active peptides used in pharmaceutical research. As a high-purity, enantiomerically pure amino acid derivative, Fmoc-D-Ser-OMe is a fundamental reagent in medicinal chemistry and biochemistry for constructing peptide-based drug candidates and probes. Its handling requires standard precautions for laboratory chemicals.