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    872143-57-2

    Catalog No. EBD4025786

    CAS 872143-57-2

    Name (5AR,10bS)-2-(pentafluorophenyl)-2,5a,6,10b-tetrahydro-4H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate

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    Basic Information

    Synonyms: (5aR,10bS)-2-(pentafluorophenyl)-2,5a,6,10b-tetrahydro-4H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-iumtetrafluoroborate (5Ar,10Bs)-(+)-5A,10B-Dihydro-2-(Pentafluorophenyl)-4H,6H-Indeno[2,1-B][1,2,4]Trizolo[4,3-D][1,4]OxaziniumTetrafluoroborate (5aR,10bS)-5a,10b-Dihydro-2-(2,3,4,5,6-pentafluorophenyl)-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazinium Tetrafluoroborate

    Molecular Formula: C18H11BF9N3O

    Molecular Weight: 467.1

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

    Product Description:
    This compound, with the CAS number 872143-57-2, is a complex heterocyclic salt. Its systematic name is (5aR,10bS)-2-(Pentafluorophenyl)-2,5a,6,10b-tetrahydro-4H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate. It features a fused polycyclic structure containing indene, triazole, and oxazine rings, substituted with a pentafluorophenyl group and a tetrafluoroborate counterion. Extensive patent and research literature identifies this compound as a key intermediate in the synthesis of novel pharmaceutical agents. Specifically, it is a crucial building block for the development of positive allosteric modulators (PAMs) of the metabotropic glutamate receptor subtype 5 (mGluR5). These mGluR5 PAMs are being investigated as potential therapeutics for central nervous system disorders, including schizophrenia, cognitive deficits, and Fragile X syndrome. The synthesis and use of this intermediate are detailed in patents related to the preparation of potent and selective mGluR5 modulators. Its complex, chiral structure is designed to impart specific pharmacological properties to the final drug candidates. As a specialized synthetic intermediate, it is primarily of interest in medicinal chemistry research and preclinical drug development.
    Physical Properties
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