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    871231-45-7

    Catalog No. EBD1070

    CAS 871231-45-7

    Name Potassium 3-hydroxyphenyltrifluoroborate

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    Basic Information

    Synonyms: Potassium3-hydroxyphenyltrifluoroborate

    Molecular Formula: C6H5BF3KO

    Molecular Weight: 200.01

    Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

    Product Description:
    Potassium 3-hydroxyphenyltrifluoroborate is an organoboron reagent, specifically an aryltrifluoroborate salt. It features a phenyl ring substituted with a hydroxyl group at the meta position and a potassium trifluoroborate group. This compound is a stable, air- and moisture-tolerant solid, making it a practical alternative to traditional boronic acids in many synthetic applications. Its primary utility lies in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. The trifluoroborate moiety serves as a protected form of the boronic acid, offering enhanced stability while remaining reactive under standard palladium-catalyzed coupling conditions. The presence of the phenolic hydroxyl group makes it a versatile building block for constructing biaryl structures containing a phenol functionality, which are common motifs in pharmaceuticals, agrochemicals, and advanced materials. It is frequently employed in the synthesis of complex molecules, including potential drug candidates and their intermediates. As a bifunctional reagent (bearing both a coupling handle and a reactive hydroxyl group), it allows for sequential functionalization, streamlining the synthesis of diversely substituted aromatic compounds. Its stability simplifies handling and storage compared to its boronic acid counterpart.
    Physical Properties

    Melting Point: 170-190 °C

    mg g kg ml l t