4-Boc-3(R)-morpholinecarboxylic acid, CAS No. 869681-70-9

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869681-70-9

Catalog No. EBD39619

CAS 869681-70-9

Name 4-Boc-3(R)-morpholinecarboxylic acid

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Basic Information

Synonyms: (R)-4-Boc-morpholine-3-carboxy (r)-n-boc-morpholine-3-carboxylicacid 3,4-morpholinedicarboxylicacid,4-(1,1-dimethylethyl)ester,(3r)- (r)-4-(tert-butoxycarbonyl)morpholine-3-carboxylicacid (3r)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylicacid (r)-n-tert-butoxycarbonylmorpholine-3-carboxylicacid (r)-4-n-boc-3-morpholinecarboxylicacid (3R)-4-(tert-butoxycarbonyl)morpholine-3-carboxylicacid (R)-Morpholine-3,4-dicarboxylicacid4-tert-butylester: (R)-Morpholine-3,4-dicarboxylicacid4-tert-butylester 4-Boc-3(R)-morpholinecarboxylicacid

Molecular Formula: C10H17NO5

Molecular Weight: 231.25

MDL Number: MFCD04114909

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

4-Boc-3(R)-morpholinecarboxylic acid is a chiral morpholine derivative characterized by a carboxylic acid group at the 3-position and a tert-butoxycarbonyl (Boc) protecting group at the nitrogen atom (4-position). This compound serves as a versatile and important chiral building block in organic synthesis, particularly in the pharmaceutical industry. Its primary application is as a key synthetic intermediate in the preparation of various active pharmaceutical ingredients (APIs). The chiral morpholine scaffold is a privileged structure found in numerous drug candidates and marketed drugs targeting diverse therapeutic areas, including central nervous system disorders, oncology, and infectious diseases. The Boc-protected nitrogen and the carboxylic acid handle provide orthogonal sites for further functionalization and coupling reactions, enabling efficient construction of complex molecules. As a commercially available chiral synthon, it facilitates the introduction of the morpholine moiety with defined stereochemistry into target molecules, which is crucial for achieving desired biological activity and pharmacokinetic properties. Its utility underscores its role in modern medicinal chemistry for the development of novel therapeutics.

Physical Properties

Boiling Point: 369.5 °C at 760 mmHg

Flash Point: 177.3 °C

Density: 1.23 g/cm3