2-Bromoethoxy-t-butyl dimethylsilane, CAS No. 86864-60-0

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86864-60-0

Catalog No. EBD34109

CAS 86864-60-0

Name 2-Bromoethoxy-t-butyl dimethylsilane

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Basic Information

Synonyms: 2-Bromoethoxy-t-butyldimethylsilane (2-bromoethoxy)-tert-butyldimethylsilane hebeifulongimportandexportco.,ltd 2-(t-butyldimethylsiloxy)ethylbromide 2-bromethanoltbdmsether (2-bromoethoxy)dimethyl-tert-butylsilane (2-bromoethoxy)-tert-butyldimethylsilane,98+%,stabilized (t-butyldimethylsiloxy)-2-ethylbromide (2-Bromoethoxy)(tert-butyl)dimethylsilane silane,(2-bromoethoxy)(1,1-dimethylethyl)dimethyl- 2-bromoethoxy-tert-butyldimethylsilane (tert-butyl)(2-bromoethoxy)dimethylsilane 2-(tert-butyldimethylsilyloxy)bromoethane 2-bromoethyloxy(tert-butyl)dimethylsilane 2-bromoethyltert-butyldimethylsilylether 2-(tert-butyldimethylsilyloxy)ethylbromide 1-(tert-butyldimethylsilyloxy)-2-bromoethane 2-(tert-butyldimethylsilyloxy)-1-bromoethane 1-bromo-2-[(tert-butyldimethylsilyl)oxy]ethane (2-bromoethoxy)(1,1-dimethylethyl)dimethylsilane (2-bromoethoxy)dimethyl(1,1-dimethylethyl)silane [(2-bromoethyl)oxy](1,1-dimethylethyl)dimethylsilane

Molecular Formula: C8H19BrOSi

Molecular Weight: 239.23

MDL Number: MFCD00209550

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Special Functional Group Blocks

Product Description:

2-Bromoethoxy-t-butyl dimethylsilane is a bifunctional organic compound featuring a bromoethoxy group and a tert-butyldimethylsilyl (TBDMS) protecting group. It serves as a versatile building block in organic synthesis, particularly in the preparation of complex molecules. Its primary application is as a reagent for the introduction of the 2-hydroxyethyl moiety in a protected form. The bromine atom acts as a good leaving group for nucleophilic substitution reactions (e.g., with amines, thiols, or stabilized carbanions), while the TBDMS group protects the resulting alcohol from unwanted reactions during subsequent synthetic steps. After the desired transformations, the TBDMS group can be selectively removed under mild acidic conditions (e.g., using tetra-n-butylammonium fluoride, TBAF) to reveal the free alcohol. This makes it valuable in the synthesis of pharmaceuticals, agrochemicals, and advanced materials where ethylene glycol linkers or side chains are required. The compound is moisture-sensitive and typically handled under inert atmosphere. It is commercially available and used as a key intermediate in multi-step synthetic routes.

Physical Properties

Boiling Point: 70-75 °C/2.5 mmHg(lit.)

Flash Point: 73 °C

Density: 1.115 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.444(lit.)