(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride, CAS No. 866783-13-3

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866783-13-3

Catalog No. EBD29397

CAS 866783-13-3

Name (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride

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Basic Information

Synonyms: (1s)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutanehcl (1s)-4,5-dimethoxy-1-(methylaminoethyl)benzocyclobutanehcl (s)-n-[(4,5-dimethoxybenzocyclobut-1-yl)methyl]-n-methylamineh (s)-(4,5-dimethoxy-1,2-dihydrocyclobutabenzen-1-yl)methanamine 3,4-dimethoxy-n-methyl-bicyclo[4.2.0]octa-1,3,5-triene-7-methanaminehydrochloride bicyclo[4.2.0]octa-1,3,5-triene-7-methanamine,3,4-dimethoxy-n-methyl-,hydrochloride 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanaminehydrochloride (7S)-3,4-Dimethoxy-N-Methyl-Bicyclo[4,2,0]octa-1,3,5-triene-7-MethanamineHCl IntermediateofIVA1 (1s)-4,5-dimethoxy-1-((methylamino)methyl)benzocyclobutanehydrochloride

Molecular Formula: C12H18ClNO2

Molecular Weight: 243.73

MDL Number: MFCD13194843

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride is a chiral benzocyclobutane derivative featuring a methylamino-methyl substituent. It serves as a key synthetic intermediate in the preparation of various pharmaceutical compounds. This compound is notably utilized in the synthesis of Vilazodone, a medication approved for the treatment of major depressive disorder (MDD). Vilazodone is a combined serotonin reuptake inhibitor and 5-HT1A receptor partial agonist. The specific stereochemistry and functional groups of this intermediate are crucial for constructing the core structure of the active pharmaceutical ingredient (API). As a specialized building block with a defined application in central nervous system (CNS) drug manufacturing, it is primarily of interest in medicinal chemistry research and process development for antidepressant agents.

Physical Properties

Boiling Point: 338.6 °C at 760 mmHg

Flash Point: 158.6 °C