Benazeprilat, CAS No. 86541-78-8

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86541-78-8

Catalog No. EBD4413

CAS 86541-78-8

Name Benazeprilat

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Basic Information

Synonyms: (2S)-2-{[(3S)-1-(Carboxymethyl)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]amino}-4-phenylbutanoicacid (S-(R*,R*))-3-((1-Carboxy-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-aceticAcid 1H-1-benzazepine-1-aceticacid,3-[[(1S)-1-carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-,(3S)- benazeprilathclhydrate cibacen benazeprilathydrochloridehydrate cgs-14831 Benazeprilat

Molecular Formula: C22H24N2O5

Molecular Weight: 396.44

Categories: Medicinal Chemistry > APIs and Their Salts > Cardiovascular Drugs Medicinal Chemistry > Drug Impurities and Reference Standards > Impurity Standards

Product Description:

Benazeprilat is the active diacid metabolite of the prodrug benazepril, which is an angiotensin-converting enzyme (ACE) inhibitor. It functions by inhibiting the conversion of angiotensin I to the potent vasoconstrictor angiotensin II, leading to vasodilation and a reduction in blood pressure. As the pharmacologically active form, benazeprilat is primarily used in the research and development of cardiovascular therapeutics. It serves as a key reference standard and impurity standard in the quality control and pharmacokinetic studies of benazepril and related pharmaceutical formulations. Its analysis is critical for ensuring drug purity, stability, and efficacy. This compound is a zwitterionic molecule under physiological conditions and exhibits the typical profile of an ACE inhibitor metabolite, including renal excretion as a major clearance pathway. Handling requires standard laboratory precautions for pharmaceutical active ingredients.

Physical Properties

Melting Point: 270-272°C

Boiling Point: 711.3 °C at 760 mmHg

Flash Point: 384 °C

Density: 1.34 g/cm3

Analytical Data

Appearance: Crystalline Solid