2-amino-7-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrrolo[2,3-d]pyrimidin-4-one, CAS No. 86392-75-8

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86392-75-8

Catalog No. EBD122981

CAS 86392-75-8

Name 2-amino-7-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrrolo[2,3-d]pyrimidin-4-one

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Basic Information

Synonyms: 7-deaza-2'-deoxyguanosine 7-deaza-2'-deoxy-d-guanosine 7-deaza-2''-deoxyguanosine,hplcpurified,98%purewithhplcuvchromatogram 7-deaza-2′7-deaza-2'-dg 7-deaze-2'-deoxyguanosine 4h-pyrrolo[2,3-d]pyrimidin-4-one,2-amino-7-(2-deoxy-b-d-erythro-pentofuranosyl)-1,7-dihydro- 2-amino-7-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 2-amino-7-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrrolo[2,3-d]pyrimidin-4-one 2-amino-7-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrrolo[2,3-d]pyrimidin-4-one

Molecular Formula: C11H14N4O4

Molecular Weight: 266.25

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

7-Deaza-2'-deoxyguanosine is a synthetic nucleoside analog where a carbon atom replaces the nitrogen atom at the 7-position of the purine ring of deoxyguanosine. This structural modification makes it a key building block in the synthesis of oligonucleotides, particularly for antisense and diagnostic applications. Its primary application is in medicinal chemistry and biochemistry research. It serves as a crucial precursor for the synthesis of modified oligonucleotides, such as those containing 7-deaza-2'-deoxyguanosine or its derivatives. These modified oligonucleotides are valuable tools for studying nucleic acid structure, function, and interactions, and are explored in the development of therapeutic agents and molecular probes due to their altered base-pairing properties and resistance to certain enzymatic degradations. As a specialized nucleoside analog, it is not a commodity chemical but a high-value research reagent. Its handling requires standard laboratory precautions for biochemicals.

Physical Properties

Boiling Point: 621.4 ºC at 760 mmHg

Flash Point: 329.6 ºC

Density: 1.9 g/cm3