sodium glycocholate, CAS No. 863-57-0

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863-57-0

Catalog No. EBD2205681

CAS 863-57-0

Name sodium glycocholate

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Basic Information

Synonyms: sodiumglycocholate sodiumglycocholatehydrate sodiumN-(3-alpha,7-alpha,12-alpha-trihydroxy-24-oxocholan-24-yl)glycinate sodium[(3,7,12-trihydroxy-24-oxocholan-24-yl)amino]acetate sodium{[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}acetate GlycocholicAcidSodiumSalt

Molecular Formula: C26H42NNaO6

Molecular Weight: 487.6

Categories: Medicinal Chemistry > Pharmaceutical Excipients > Surfactants, Emulsifiers, and Solubilizers Medicinal Chemistry > Biochemicals and Life Science Reagents > Lipids and Derivatives

Product Description:

Sodium glycocholate is the sodium salt of glycocholic acid, a primary bile acid conjugate formed from cholic acid and glycine. It is a natural, steroidal amphiphilic molecule with a rigid steroid nucleus and a hydrophilic side chain terminated with a carboxylate group. Its primary application is as a pharmaceutical excipient, specifically a biological surfactant and absorption enhancer. It is widely used to improve the solubility and intestinal absorption of poorly water-soluble drugs, including in lipid-based drug delivery systems and self-emulsifying drug delivery systems (SEDDS). It functions by forming mixed micelles, which solubilize lipophilic compounds and can transiently increase membrane permeability. In research, sodium glycocholate serves as a key biochemical reagent in studies of bile acid metabolism, membrane biology, and as a component in simulated intestinal fluids for in vitro dissolution testing. It is also used to investigate its role in cholesterol homeostasis and as a signaling molecule.

Physical Properties

Melting Point: 210-215 °C (subl.)(lit.)

Refractivity: 30 ° (C=1, H2O)

Storage: Refrigerator

Analytical Data

Appearance: light green solid