(S)-(+)-3-Hydroxytetrahydrofuran, CAS No. 86087-23-2

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86087-23-2

Catalog No. EBD23033

CAS 86087-23-2

Name (S)-(+)-3-Hydroxytetrahydrofuran

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Basic Information

Synonyms: S(+)-3-hydroxyTetrahydrofuran (S)-3-Hydroxytetrahydrofuran (S)-tetrahydrofuran-3-ol (3S)-tetrahydrofuran-3-ol Hydroxytetrahydrofuran,(S)-(+)-3- Thiophene-3-ol,tetrahydro-,(S)- Thiophene-3-ol,tetrahydro-,(3S)- (S)-(+)-tetrahyro-3-furanol (S)-Tetrahydro-Furan-3-ol (s)-(+)-3-hydroxytetahydrofuran (s)-(-)-3-hydroxytetrahydrofuran (s)-(+)-3-hydroxytetrahydrofurane 3-furanol,tetrahydro-,(s) S-3-hydroxytetrahydrofuran (S)-(+)-3-Hydroxytetrahydrofuran

Molecular Formula: C4H8O2

Molecular Weight: 8811.0

MDL Number: MFCD00064327

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Other Organic Building Blocks

Product Description:

S-3-Hydroxytetrahydrofuran is a chiral heterocyclic compound featuring a tetrahydrofuran ring substituted with a hydroxyl group at the 3-position. It is a versatile and valuable chiral building block in organic synthesis, particularly valued for its (S)-configuration. Its primary and most significant application is as a key chiral intermediate in the pharmaceutical industry. It is notably used in the synthesis of various active pharmaceutical ingredients (APIs), including antiviral drugs, HIV protease inhibitors, and other therapeutics where the specific stereochemistry is crucial for biological activity. The molecule serves as a precursor for constructing complex molecular architectures. Beyond its pharmaceutical applications, S-3-Hydroxytetrahydrofuran is also employed as a starting material or intermediate in the synthesis of chiral ligands, catalysts, and other fine chemicals. Its utility stems from the reactivity of both the hydroxyl group and the tetrahydrofuran ring, allowing for diverse chemical transformations.

Physical Properties

Boiling Point: 80 °C/15 mmHg(lit.)

Flash Point: 79 °C

Density: 1.103 g/mL at 25 °C(lit.)

Solubility: soluble

Refractivity: n20/D 1.45(lit.)

Safety Information

Packing Level: III

Hazard Category: /

Transport Codes: 1993

Analytical Data

Appearance: clear liquid