3,4,5-Trimethoxybenzaldehyde, CAS No. 86-81-7

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86-81-7

Catalog No. EBD25552

CAS 86-81-7

Name 3,4,5-Trimethoxybenzaldehyde

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Basic Information

Synonyms: 3,4,5-Trimethoxybenzaldehyde 4-08-00-02719(BeilsteinHandbookReference) AI3-36673 BENZALDEHYDE,3,4,5-TRIMETHOXY- BRN0395163 NSC16692 TMBA

Molecular Formula: C10H12O4

Molecular Weight: 196.2

MDL Number: MFCD00003364

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones

Product Description:

3,4,5-Trimethoxybenzaldehyde is an organic compound with the molecular formula C10H12O4. It is a white to off-white crystalline powder characterized by its aromatic aldehyde functional group flanked by three methoxy substituents at the 3, 4, and 5 positions. This specific substitution pattern makes it a valuable and versatile chemical building block. Its primary and most significant application is in the pharmaceutical industry as a key synthetic intermediate. It serves as a crucial precursor in the synthesis of Trimethoprim, a widely used antibiotic that inhibits bacterial dihydrofolate reductase. Beyond this, it is also employed in the synthesis of other bioactive molecules, including certain vasodilators and compounds with potential anticancer activity. Due to its well-defined reactive aldehyde group and electron-rich aromatic system, 3,4,5-Trimethoxybenzaldehyde is a common starting material in organic synthesis for constructing more complex molecular architectures. It is frequently used in condensation reactions, such as the Knoevenagel condensation, to form carbon-carbon bonds.

Physical Properties

Melting Point: 72-74 °C(lit.)

Boiling Point: 163-165 °C/10 mmHg(lit.)

Flash Point: 163-165°C/10mm

Density: 1.133 g/cm3

Solubility: methanol: 0.1 g/mL, clear

Analytical Data

Appearance: white to creamy powder or flakes