3,5 - Dimethylpyrazole - 4 - boronic acid pinacol ester, CAS No. 857530-80-4

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857530-80-4

Catalog No. EBD45972

CAS 857530-80-4

Name 3,5 - Dimethylpyrazole - 4 - boronic acid pinacol ester

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Basic Information

Synonyms: 3,5-Dimet 3,5-Dimethylpyrazole-4-BoronicAcid,PinacolEster 3,5-dimethyl-1h-pyrazole-4-boronicacid,pinacolester 3,5-dimethyl-pyrazole-4-boronicacid 3,5-dimethylpyrazole-4-boronicacidpinacolester,97% 5-dimethylpyrazole-4-boronicacidpinacolester 3,5-dimethyl-4-pyrazoleboronicacidpinacolester 3,5-Dimethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1H-pyrazole,3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 3,5-Dimethylpyrazole-4-boronicacidpinacolester (3,5-dimethyl-1h-pyrazol-4-yl)boronicacidpinacolester

Molecular Formula: C11H19BN2O2

Molecular Weight: 222.09

Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

3,5-Dimethylpyrazole-4-boronic acid pinacol ester is a heterocyclic organoboron compound. It features a pyrazole ring substituted with two methyl groups and a boronic ester functional group. This structure makes it a valuable building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, which are pivotal for constructing biaryl and heterobiaryl systems. Its primary application is as a key synthetic intermediate in medicinal chemistry. The pyrazole moiety is a privileged scaffold in drug discovery, and this specific boronic ester derivative is utilized to introduce the 3,5-dimethylpyrazol-4-yl group into target molecules. It is instrumental in the research and development of various pharmaceutical compounds, including potential kinase inhibitors and other biologically active agents. As a solid, it requires careful handling under inert conditions due to the sensitivity of the boronic ester group to protic solvents and air/moisture over prolonged periods. It is a specialty chemical primarily supplied for research and development purposes in academic and industrial laboratories focused on synthetic and medicinal chemistry.

Physical Properties

Melting Point: 163-168 °C(lit.)

Boiling Point: 364.5°C at 760 mmHg

Flash Point: 174.3°C

Density: 1.05g/cm3