(4-((2-(Dimethylamino)ethyl)carbamoyl)phenyl)boronic acid hydrochloride, CAS No. 850568-22-8

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850568-22-8

Catalog No. EBD2220743

CAS 850568-22-8

Name (4-((2-(Dimethylamino)ethyl)carbamoyl)phenyl)boronic acid hydrochloride

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Basic Information

Synonyms: (4-((2-(Dimethylamino)ethyl)carbamoyl)phenyl)boronicacidhydrochloride 4-(2-(dimethylamino)ethylcarbamoyl)phenylboronicacid,hcl 4-[2-(n,n-dimethylaminoethyl)aminocarbonyl]benzeneboronicacidhydrochloride 4-[2-(n,n-dimethylaminoethyl)aminocarbonyl]phenylboronicacid,hcl 4-(2-dimethylamino)ethylcarbamoyl)phenylboronicacid,hydrochloride 4-{[2-(dimethylamino)ethyl]carbamoyl}benzeneboronicacidhydrochloride 4-borono-n-[2-(dimethylamino)ethyl]benzamidehydrochloride 4-(2-(dimethylamino)ethylcarbamoyl)phenylboronicacid [4-(2-dimethylaminoethylcarbamoyl)phenyl]boronicacidhydrochloride

Molecular Formula: C11H18BClN2O3

Molecular Weight: 272.54

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters

Product Description:

4-(2-(Dimethylamino)ethylcarbamoyl)phenylboronic acid hydrochloride is a boronic acid derivative featuring a phenylboronic acid core substituted with a dimethylaminoethylcarbamoyl group. The compound is supplied as its hydrochloride salt, which typically enhances its stability and solubility for handling and storage in synthetic applications. This compound is primarily utilized as a key synthetic building block, or "pharmaceutical intermediate," in medicinal chemistry research and drug discovery. The phenylboronic acid moiety is a crucial functional group in Suzuki-Miyaura cross-coupling reactions, a widely employed method for constructing biaryl bonds. The appended dimethylaminoethylcarbamoyl group can serve as a solubilizing or targeting element, making this reagent particularly valuable for synthesizing complex molecules, including potential active pharmaceutical ingredients (APIs) and bioactive probes. Its specific structural features position it as a bifunctional reagent, combining the cross-coupling capability of the boronic acid with the potential for further modification or interaction through the amide and tertiary amine functionalities. As such, it falls under the category of specialized organic synthesis building blocks used in the development of pharmaceutical candidates.

Physical Properties

Melting Point: 186-190

Boiling Point: 476°C at 760 mmHg

Flash Point: 241.7°C