9-Fluorenylmethyl carbamate, CAS No. 84418-43-9

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84418-43-9

Catalog No. EBD54105

CAS 84418-43-9

Name 9-Fluorenylmethyl carbamate

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Basic Information

Synonyms: n-(9-fluorenylmethoxycarbonyl)amide fmoc-nh2 fmoc-amide 9-(fluorenylmethylcarbonyl)amide 9-fluorenemethaneresin fmoc-nh2(9-fluorenylmethylcarbamate) 9-fluorenylcarbamate 9-Fluorenylmethylcarbamate 9H-fluoren-9-ylmethylcarbamate

Molecular Formula: C15H13NO2

Molecular Weight: 239.27

MDL Number: MFCD00237376

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Other Organic Building Blocks

Product Description:

Fmoc-NH2, with CAS number 84418-43-9, is a chemical compound known as 9-Fluorenylmethyl carbamate or Fmoc-amide. It serves as a crucial building block and reagent in organic synthesis, particularly in the field of peptide chemistry. Its primary function is as a protected form of ammonia, where the Fmoc (9-fluorenylmethoxycarbonyl) group acts as a temporary protecting group for the amino functionality. The most significant application of Fmoc-NH2 is in solid-phase peptide synthesis (SPPS). It is used to introduce the Fmoc-protected amino group at the N-terminus of peptides or as a reagent for the synthesis of Fmoc-protected amino acids and other Fmoc-derivatized intermediates. The Fmoc group is highly favored due to its stability under acidic conditions and its clean removal under mild basic conditions (e.g., using piperidine), making it orthogonal to other protecting group strategies like Boc (tert-butoxycarbonyl). This compound is a fundamental and specialized reagent in bioconjugation and the production of peptide-based pharmaceuticals, diagnostics, and research tools. It is not a general-purpose chemical but a targeted synthon for constructing complex biomolecules and their analogs.

Physical Properties

Melting Point: 201-204 °C

Boiling Point: 459.7 °C at 760 mmHg

Flash Point: 242.3 °C

Density: 1.239 g/cm3

Solubility: dioxane: 15 mg/mL, clear, colorless

Storage: 2-8°C