(S)-(-)-3-Amino-3-phenylpropionic acid hydrochloride, CAS No. 83649-47-2

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83649-47-2

Catalog No. EBD24470

CAS 83649-47-2

Name (S)-(-)-3-Amino-3-phenylpropionic acid hydrochloride

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Basic Information

Synonyms: (S)-3-amino-3-phenylpropionicacidhydrochloride L-(+)-3-amino-3-phenylpropionicacidhydrochloride d-beta-homophenylglycinehydrochloride h-d-phg-(c*ch2)ohhcl (s)-3-amino-3-phenylpropanoicacidhydrochloride (s)-(+)-3-amino-3-phenylpropionicacidhcl (s)-(+)-3-amino-3-phenylpropionicacidhydrochloride rarechemakpt0078 l-beta-phenylalaninehcl l-3-amino-3-phenylpropionicacidhydrochloride (S)-3-Amino-3-phenylpropanoicAcidHydrochlorideS Benzenepropanoicacid,β-amino-,(betaS)-,hydrochloride(1:1) S-3-Amino-3-phenyl-propionicacidhydrochloride (S)-(-)-3-Amino-3-PhenylpropionicAcidHydrochloride (s)-(+)-3-amino-3-phenylpropionicacidhydrochlo

Molecular Formula: C9H18ClNO2

Molecular Weight: 207.7

MDL Number: MFCD03092945

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-3-Amino-3-phenylpropionic acid hydrochloride is a chiral organic compound featuring a phenyl group and a carboxylic acid group attached to a central carbon bearing an amino group, all in the (S)-configuration. It is typically supplied as a white to off-white crystalline powder in its hydrochloride salt form to enhance stability and solubility. This compound serves as a crucial chiral building block in pharmaceutical synthesis. Its primary application is as a key intermediate in the production of various active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. For instance, it is a fundamental precursor in the synthesis of (S)-Dapoxetine, a short-acting selective serotonin reuptake inhibitor (SSRI) used to treat premature ejaculation. The chiral (S)-amino acid structure provides the necessary stereochemistry for biological activity in the final drug molecule. As a versatile synthon, it is employed in peptide mimetics research and the construction of more complex chiral molecules. Handling requires standard precautions for amino acid derivatives and hydrochloride salts, including the use of personal protective equipment to avoid inhalation or contact.

Physical Properties

Melting Point: 179-184 °C

Boiling Point: 338.4 °C at 760 mmHg

Flash Point: 158.5 °C

Analytical Data

Appearance: white to light yellow crystal powde