(4-(Benzyloxy)phenyl)methanol, CAS No. 836-43-1

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836-43-1

Catalog No. EBD2210627

CAS 836-43-1

Name (4-(Benzyloxy)phenyl)methanol

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Basic Information

Synonyms: (4-(Benzyloxy)phenyl)methanol 4-Benzyloxybenzylalcohol p-benzyloxybenzylchloride benzenemethanol,4-(phenylmethoxy)- p-benzyloxybenzylalcohol (4-benzyloxyphenyl)methanol 4-(benzyloxy)benzylalcohol 4-(phenylmethoxy)benzenemethanol benzylalcohol,p-(benzyloxy)-(6ci,7ci,8ci)

Molecular Formula: C14H14O2

Molecular Weight: 214.26

MDL Number: MFCD00004654

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers

Product Description:

4-Benzyloxybenzyl alcohol is an organic compound featuring a benzyl-protected phenol group and a primary alcohol functional group. It serves as a versatile and crucial synthetic intermediate in organic chemistry, particularly in pharmaceutical research and development. Its primary application is as a key building block in the synthesis of various biologically active molecules. For instance, it is a documented precursor in the synthesis of selective estrogen receptor modulators (SERMs) and other pharmacologically relevant compounds. The benzyloxy group acts as a protecting group for the phenolic hydroxyl, which can be selectively deprotected at a later synthetic stage, while the hydroxymethyl group can be further functionalized through oxidation, esterification, or etherification reactions. This compound is a valuable tool for medicinal chemists, enabling the construction of complex molecular architectures. It is typically handled under standard laboratory conditions, and its reactivity is governed by the interplay between the protected phenol and the primary alcohol functionalities.

Physical Properties

Melting Point: 86-87 °C(lit.)

Boiling Point: 371.9 °C at 760 mmHg

Flash Point: 170.6 °C

Density: 1.139 g/cm3

Storage: Store at RT.

Analytical Data

Appearance: off-white powder