(S)-1-Phenyl-3-propanolamin, CAS No. 82769-76-4

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82769-76-4

Catalog No. EBD2202905

CAS 82769-76-4

Name (S)-1-Phenyl-3-propanolamin

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Basic Information

Synonyms: (s)-3-amino-3-phenylpropan-1-ol (s)-beta-phenylalaninol (s)-3-amino-3-phenylpropan-1-ol(e.e.) (s)-3-amino-3-phenylpropan-1-ol,98%ee,95% (s)-3-phenyl-beta-alaninol (s)-3-amino-3-phenylpropanol (s)-3-amino-3-phenylpropan-1-ol,95%,ee:98% (S)-3-Amino-3-phenylpropi-1-ol (S)-3-Amino-3-phenylpropan-l-ol (3S)-3-amino-3-phenyl-propan-1-olhydrochloride Benzenepropanol,γ-amino-,(γS)- (S)-1-Phenyl-3-propanolamin

Molecular Formula: C9H13NO

Molecular Weight: 151.21

MDL Number: MFCD01311768

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-3-Amino-3-phenylpropan-1-ol is a chiral amino alcohol compound featuring a phenyl group and both amino and hydroxyl functionalities on a three-carbon chain. It is a white to off-white crystalline powder. This compound serves as a crucial chiral building block in pharmaceutical synthesis. Its primary application is as a key intermediate in the production of (S)-dapoxetine, a short-acting selective serotonin reuptake inhibitor (SSRI) used for the treatment of premature ejaculation. The (S)-enantiomer is the pharmacologically active form. The molecule's structure allows for further chemical modifications, making it valuable for constructing more complex chiral targets in medicinal chemistry. As a bifunctional chiral synthon containing both amine and alcohol groups, it is also utilized in asymmetric synthesis and as a precursor for ligands or catalysts. It should be handled with appropriate safety precautions in a well-ventilated laboratory environment.

Physical Properties

Boiling Point: 293 °C at 760 mmHg

Flash Point: 131 °C

Density: 1.074 g/cm3

Analytical Data

Appearance: colorless viscous liquid