2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile, CAS No. 82671-02-1

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82671-02-1

Catalog No. EBD26380

CAS 82671-02-1

Name 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

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Basic Information

Synonyms: 3-Cyano-2,6-dichloro-5-fluoropyridine 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile 2,6-Dichloro-3-cyano-5-fluoropyridine 3-cyano-5-fluoro-2,6-Dihydroxypyridine 5-Fluoro-2,6-Dichloronicotinonotrile 2,6-dichloro-5-fluoronicotinonitrile 2,6-dichloro-3-cyano-5-fluoropyridine,98% 2,6-dichloro-3-cyano-5-flroro-pyridine 3-cyano-2,6-dichloro-5-fluoropyridine97%

Molecular Formula: C6HCl2FN2

Molecular Weight: 190.99

MDL Number: MFCD01863289

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Cyano Compounds

Product Description:

2,6-Dichloro-5-fluoro-3-cyanopyridine is a halogenated and cyano-substituted pyridine derivative. It serves as a key heterocyclic building block in pharmaceutical synthesis. The presence of multiple reactive sites (chloro, fluoro, and cyano groups) makes it a versatile intermediate for constructing more complex molecular structures. Its primary and well-documented application is as a crucial intermediate in the synthesis of fluoroquinolone antibiotics. It is specifically used in the production of third-generation fluoroquinolones, such as Levofloxacin and its analogs. The compound provides the core pyridine scaffold that is further elaborated to form the essential quinolone pharmacophore, contributing to the antibacterial activity of the final drug molecules. Due to its defined role in drug manufacturing, it is categorized primarily as a pharmaceutical intermediate. Its structural features also align it with general-purpose organic synthesis building blocks, particularly those containing cyano functional groups.

Physical Properties

Melting Point: 89-91 °C(lit.)

Boiling Point: 267.8 °C at 760 mmHg

Flash Point: 115.8 °C

Density: 1.58 g/cm3