2,4-Difluorophenylacetic acid, CAS No. 81228-09-3

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81228-09-3

Catalog No. EBD36832

CAS 81228-09-3

Name 2,4-Difluorophenylacetic acid

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Basic Information

Synonyms: Octane,1,8-dibromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-hexadecafluoro- (2,4-difluorophenyl)acetate 2,4-difluoro-Benzeneaceticacid benzeneaceticacid,2,4-difluoro- rarechemalbo0247 2,4-difluorophenylaceticacid,99% 2,4-difluorophenylaceticacid97% 2,4-ddifluorophenylaceticacid,97% 1,8-Dibromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-hexadecafluorooctane 2,4-Difluorophenylaceticacid 2-(2,4-difluorophenyl)aceticacid (2,4-difluoro-phenyl)-aceticacid (2,4-Difluorophenyl)aceticacid

Molecular Formula: C8H6F2O2

Molecular Weight: 172.13

MDL Number: MFCD00009999

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

2,4-Difluorophenylacetic acid is an organic compound featuring a phenylacetic acid core substituted with fluorine atoms at the 2- and 4- positions. It is a white to off-white crystalline powder and serves as a versatile building block in organic synthesis. This compound is primarily utilized as a key pharmaceutical intermediate. Its most notable application is in the synthesis of Fluconazole, a widely used broad-spectrum triazole antifungal agent. The difluorophenyl moiety is a crucial structural component that contributes to the drug's potency and pharmacokinetic properties. Beyond Fluconazole, it is also employed in the research and development of other bioactive molecules, including potential anticancer agents and enzyme inhibitors, where the introduction of fluorine atoms can modulate lipophilicity, metabolic stability, and binding affinity. As a bifunctional molecule containing both an aromatic ring and a carboxylic acid group, it is a valuable synthon for constructing more complex molecular architectures through reactions such as amidation, esterification, and further functionalization of the aromatic ring.

Physical Properties

Melting Point: 115-118 °C(lit.)

Boiling Point: 257.2 °C at 760 mmHg

Flash Point: 109.4 °C

Density: 1.373 g/cm3

Solubility: very soluble in water

Analytical Data

Appearance: white crystal